CAS No. 1933528-96-1
Batch:
Purity:99.94
Chemical Structure
Check the
MDR-652
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1933528-96-1 | |
|---|---|---|
| Molecular Formula |
C22H23ClFN3O2S |
|
| Molecular Weight (MW) | 447.95 | |
| SMILES | CC(C)(C)C1=NC(=C(S1)CNC(=O)NC2=CC(=C(C=C2)CO)F)C3=CC(=CC=C3)Cl |
MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1). Activation of TRPV1 by MDR-652 modulates cation influx in sensory neurons, leading to desensitization of nociceptive nerve fibers. This pathway modulation results in dose-dependent analgesic effects and attenuation of pain signaling without inducing traditional pungency. Consequently, MDR-652 serves as a valuable tool for investigating TRPV1 channel gating and nociceptive signaling pathways. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(200.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 90 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.