CAS No. 29218-27-7
Batch:
Purity:99.85
Chemical Structure
Check the
Toloxatone (MD69276)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one | |
|---|---|---|
| CAS Number | 29218-27-7 | |
| Molecular Formula |
C11H13NO3 |
|
| Molecular Weight (MW) | 207.23 | |
| SMILES | CC1=CC(=CC=C1)N2CC(OC2=O)CO | |
| InChIKey | MXUNKHLAEDCYJL-UHFFFAOYSA-N |
Toloxatone (MD69276) is a reversible inhibitor of monoamine oxidase A (MAO-A). By inhibiting MAO-A, it prevents the oxidative catabolism of monoamine neurotransmitters, resulting in increased levels of serotonin, norepinephrine, and dopamine within central nervous system pathways. This accumulation enhances monoaminergic neurotransmission, leading to significant neuroprotective and antidepressant functional phenotypes in preclinical models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
41 mg/mL
(197.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 41 mg/mL |
| Water | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.