CAS No. 2249801-12-3
Batch:
Purity:99.78
Chemical Structure
Check the
MD2-TLR4-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2,6-dichloro-N-[3-(1H-indol-5-yl)-1H-indazol-5-yl]benzamide | |
|---|---|---|
| CAS Number | 2249801-12-3 | |
| Molecular Formula |
C22H14Cl2N4O |
|
| Molecular Weight (MW) | 421.28 | |
| SMILES | C1=CC(=C(C(=C1)Cl)C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC5=C(C=C4)NC=C5)Cl | |
| InChIKey | AZPDJGLJPDRCDQ-UHFFFAOYSA-N |
MD2-TLR4-IN-1 is a potent inhibitor of the myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex. By targeting MD2-TLR4, the compound effectively blocks lipopolysaccharide (LPS)-induced signaling pathways. Consequently, it suppresses downstream pro-inflammatory phenotypes, inhibiting the production of key inflammatory cytokines including tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophage cell models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(199.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.