CAS No. 521310-51-0

Batch: Purity:99.88
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MCP110 Chemical Structure
Chemical Structure
Check the MCP110 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(3-methoxy-4-phenylmethoxyphenyl)methyl]-5-phenyl-N-(2-pyridin-2-ylethyl)pentanamide
CAS Number 521310-51-0
Molecular Formula

C33H36N2O3
Molecular Weight (MW) 508.65
SMILES COC1=CC(=CC=C1OCC2=CC=CC=C2)CN(CCC3=NC=CC=C3)C(=O)CCCCC4=CC=CC=C4
InChIKey JWLZIHLAMJDONF-UHFFFAOYSA-N

Biological Activity

MCP110 is a small-molecule inhibitor that targets the Ras/Raf-1 protein-protein interaction. By selectively disrupting the binding of activated GTP-bound Ras to Raf-1 kinase, MCP110 blocks downstream MAPK/ERK signaling pathway activation. Consequently, treatment with MCP110 suppresses downstream ERK phosphorylation, reverts Ras-mediated oncogenic transformation, and significantly reduces cell proliferation and anchorage-independent growth in Ras-dependent cancer cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (196.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kato-Stankiewicz J, et al. Proc Natl Acad Sci U S A. 2002;99(22):14398-403.

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Note: Technical data last updated: Sep 1, 2026.