Cell-free Assays (IC50/Ki) for MCC950 Sodium
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| NLRP3 inflammasome | < 10 nM | Inhibition of NLRP3 inflammasome oligomerization and activation assay | PMC6432065 |
Cell-based Assay (IC50) for MCC950 Sodium
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| human monocytic THP-1 cells | 3.4 nM | IL-1β ELISA | Download PDF |
| primary mouse microglia | 4.7 nM | IL-1β ELISA | Download PDF |
| human monocyte-derived macrophages (HMDM) | 3.4 nM | IL-1β ELISA | Download PDF |
| human monocyte-derived microglia (MDMi) | 3.9 nM | IL-1β ELISA | Download PDF |
| HEK293-NLRP3/CASP1-iASC-CASPorter cells | 0.46 μM | Flow cytometric analysis of GFP+ population, processed by nonlinear regression analysis (inhibitor versus normalized response, variable slope) using Prism Software. | PMC8865862 |
Check the
MCC950 Sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
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- MCC950 Sodium Working Concentration | Cell Culture | Treatment
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