CAS No. 1995067-59-8
Batch:
Purity:98.08
Chemical Structure
Check the
Emlenoflast (MCC-7840)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1995067-59-8 | |
|---|---|---|
| Molecular Formula |
C19H24N4O3S |
|
| Molecular Weight (MW) | 388.49 | |
| SMILES | CC(C)[N]1C=CC(=N1)[S;v6](=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4 |
Emlenoflast (MCC-7840) is a sulfonylurea derivative that acts as a potent and selective inhibitor of the NLRP3 inflammasome, demonstrating nanomolar potency in human and mouse microglia. Selective inhibition of the NLRP3 inflammasome complex prevents caspase-1 activation and suppresses the downstream maturation and release of proinflammatory cytokines IL-1β and IL-18. This targeted blockade attenuates neuroinflammation and preserves dopaminergic neuronal integrity in preclinical models. [1][2]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(200.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
82 mg/mL
(211.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.