CAS No. 851528-79-5
Batch:
Purity:99.55
Chemical Structure
Check the
Seladelpar
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[4-[(2R)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]sulfanyl-2-methylphenoxy]acetic acid | |
|---|---|---|
| CAS Number | 851528-79-5 | |
| Molecular Formula |
C21H23F3O5S |
|
| Molecular Weight (MW) | 444.47 | |
| InChIKey | JWHYSEDOYMYMNM-QGZVFWFLSA-N |
Seladelpar (MBX-8025) functions as a potent and selective agonist targeting peroxisome proliferator-activated receptor-delta (PPAR-δ). Ligand binding to PPAR-δ stimulates transcriptional networks that drive fatty acid oxidation and lipid clearance pathways. Downstream activation enhances insulin sensitivity, improves plasma lipid profiles, and reduces hepatic storage of lipotoxic lipids, thereby ameliorating metabolic dysregulation and hepatic steatosis phenotypes. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(200.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 89 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(224.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.