CAS No. 188343-77-3
Batch:
Purity:99.80
Chemical Structure
Check the
MBP146-78
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine | |
|---|---|---|
| CAS Number | 188343-77-3 | |
| Molecular Formula |
C21H22FN3 |
|
| Molecular Weight (MW) | 335.42 | |
| SMILES | CN1CCC(CC1)C2=CC(=C(N2)C3=CC=C(C=C3)F)C4=CC=NC=C4 | |
| InChIKey | RBWNFHXBUDPAIO-UHFFFAOYSA-N |
MBP146-78 is a potent and selective inhibitor of cyclic GMP (cGMP)-dependent protein kinase (PKG). By targeting PKG, it disrupts cGMP-mediated signaling cascades crucial for parasitic processes, including microneme secretion and host cell motility. Consequently, inhibition of PKG leads to downstream disruption of parasite egress and host invasion, demonstrating cytostatic activity against Toxoplasma gondii. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12 mg/mL
(35.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.