CAS No. 558447-26-0
Batch:
Purity:99.08
Chemical Structure
Check the
Mavorixafor
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N'-(1H-benzimidazol-2-ylmethyl)-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine | |
|---|---|---|
| CAS Number | 558447-26-0 | |
| Molecular Formula |
C21H27N5 |
|
| Molecular Weight (MW) | 349.47 | |
| InChIKey | WVLHHLRVNDMIAR-IBGZPJMESA-N |
Mavorixafor (AMD-070) is a potent, selective antagonist of chemokine receptor CXCR4, exhibiting an IC50 value of 13 nM against CXCR4 125I-SDF binding. Target inhibition disrupts the CXCL/CXCR4 signaling axis, inhibiting downstream activation of MAPK and AKT signaling cascades. Consequently, this blockade suppresses CXCL-mediated cell migration, chemotaxis, and invasion, while also inhibiting T-tropic HIV-1 viral replication in host cells. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(200.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 70 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.