CAS No. 359875-09-5
Batch:
Purity:99.52
Chemical Structure
Check the
Maropitant citrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 359875-09-5 | |
|---|---|---|
| Molecular Formula |
C32H40N2O.C6H8O7.H2O |
|
| Molecular Weight (MW) | 678.82 | |
| SMILES | O.COC1=C(CNC2C3CCN(CC3)C2C(C4=CC=CC=C4)C5=CC=CC=C5)C=C(C=C1)C(C)(C)C.OC(=O)CC(O)(CC(O)=O)C(O)=O |
Maropitant citrate is a novel, synthetic nonpeptide neurokinin type-1 (NK1) receptor antagonist. By selectively blocking the interaction of substance P with central and peripheral NK1 receptors, it disrupts tachykinin-mediated signaling cascades. This receptor inhibition dampens downstream neurogenic inflammation and pain signal transmission, ultimately attenuating nociceptive responses and suppressing emetic motor signaling in the central nervous system. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(147.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.