CAS No. 2271081-58-2
Batch:
Purity:99.23
Chemical Structure
Check the
MARK4 inhibitor 1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(2-hydroxy-7-methyl-1H-indol-3-yl)imino]-1-[(4-methoxyphenyl)methyl]triazole-4-carboxamide | |
|---|---|---|
| CAS Number | 2271081-58-2 | |
| Molecular Formula |
C20H18N6O3 |
|
| Molecular Weight (MW) | 390.4 | |
| SMILES | COC1=CC=C(C[N]2C=C(N=N2)C(=O)N\N=C\3C(=O)NC4=C(C)C=CC=C34)C=C1 | |
| InChIKey | KACGMLSYPGROFF-UHFFFAOYSA-N |
MARK4 inhibitor 1 is a potent small-molecule inhibitor targeting microtubule affinity-regulating kinase 4 (MARK4). MARK4 phosphorylates microtubule-associated proteins to regulate microtubule dynamics, cell cycle progression, and cell polarity. Inhibition of MARK4 modulates downstream signaling networks including the mTOR and NF-κB pathways, suppressing cancer cell proliferation and migration while promoting apoptotic cell death.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
2 mg/mL
(5.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.