CAS No. 1253978-24-3
Batch:
Purity:99.13
Chemical Structure
Check the
MAO-B-IN-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[(E)-3-(2-chlorophenyl)prop-2-enoyl]chromen-2-one | |
|---|---|---|
| CAS Number | 1253978-24-3 | |
| Molecular Formula |
C18H11ClO3 |
|
| Molecular Weight (MW) | 310.73 | |
| SMILES | ClC1=CC=CC=C1/C=C/C(=O)C2=CC3=CC=CC=C3OC2=O | |
| InChIKey | TVTIXYCYMBPAFW-MDZDMXLPSA-N |
MAO-B-IN-2 is a halogenated coumarin-chalcone derivative functioning as a selective and competitive inhibitor of monoamine oxidase-B (MAO-B, IC50 = 0.51 μM) and butyrylcholinesterase (BChE, IC50 = 7.00 μM). By inhibiting MAO-B and BChE enzyme activities, MAO-B-IN-2 regulates neurochemical catabolic pathways and demonstrates reactive oxygen species scavenging effects, thereby attenuating hydrogen peroxide-induced oxidative stress and cellular damage. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(9.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.