CAS No. 1951408-58-4
Batch:
Purity:99.86
Chemical Structure
Check the
MAK683
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | |
|---|---|---|
| CAS Number | 1951408-58-4 | |
| Molecular Formula |
C20H17FN6O |
|
| Molecular Weight (MW) | 376.39 | |
| SMILES | CC1=C(C=CC=N1)C2=CN=C(N3C2=NN=C3)NCC4=C(C=CC5=C4CCO5)F | |
| InChIKey | XLIBABIFOBYHSV-UHFFFAOYSA-N |
Biological Activity
MAK683 is a potent inhibitor of embryonic ectoderm development (EED), a core regulatory subunit of Polycomb Repressive Complex 2 (PRC2). By binding to the H3K27me3-binding pocket of EED, MAK683 prevents PRC2 activation and suppresses its methyltransferase activity. This downstream blockade reduces cellular histone H3 lysine 27 trimethylation (H3K27me3) levels, leading to derepression of target genes and inhibition of cell proliferation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12.5 mg/mL
(33.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.