CAS No. 138-37-4

Batch: Purity:99.98
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Mafenide hydrochloride Chemical Structure
Chemical Structure
Check the Mafenide hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-(aminomethyl)benzenesulfonamide;hydrochloride
CAS Number 138-37-4
Molecular Formula

C7H10N2O2S.HCl
Molecular Weight (MW) 222.69
SMILES C1=CC(=CC=C1CN)S(=O)(=O)N.Cl
InChIKey SIACJRVYIPXFKS-UHFFFAOYSA-N

Biological Activity

Mafenide hydrochloride is a synthetic sulfonamide compound that acts as an inhibitor of the carbonic anhydrase enzyme family. By inhibiting carbonic anhydrase activity, it alters intracellular metabolic pathways and disrupts pH homeostasis within bacterial cells. This action leads to the suppression of microbial metabolic functions and inhibition of bacterial proliferation, making it an effective topical anti-infective agent. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 44 mg/mL (197.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 44 mg/mL
Ethanol 8 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Nat Rev Drug Discov. 2004;3(S7):S6-S10.

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Note: Technical data last updated: Sep 1, 2026.