CAS No. 13009-99-9
Batch:
Purity:99.59
Chemical Structure
Check the
Mafenide Acetate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | acetic acid;4-(aminomethyl)benzenesulfonamide | |
|---|---|---|
| CAS Number | 13009-99-9 | |
| Molecular Formula |
C7H10N2O2S.C2H4O2 |
|
| Molecular Weight (MW) | 246.28 | |
| SMILES | CC(=O)O.C1=CC(=CC=C1CN)S(=O)(=O)N | |
| InChIKey | UILOTUUZKGTYFQ-UHFFFAOYSA-N |
Mafenide Acetate is a synthetic sulfonamide derivative that acts as a carbonic anhydrase inhibitor and topical antimicrobial agent. By targeting carbonic anhydrase enzymes, it interferes with cellular carbon dioxide hydration, systemic pH regulation, and microbial metabolic pathways. This enzymatic inhibition disrupts bacterial acid-base homeostasis and inhibits bacterial growth, providing significant anti-infective activity against a wide range of pathogens in severe burn injuries and cutaneous tissue infections. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
49 mg/mL
(198.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 49 mg/mL |
| Ethanol | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.