CAS No. 2590556-80-0
Batch:
Purity:99.12
Chemical Structure
Check the
M4205（IDRX-42）
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine | |
|---|---|---|
| CAS Number | 2590556-80-0 | |
| Molecular Formula |
C29H32N8O |
|
| Molecular Weight (MW) | 508.62 | |
| InChIKey | LVMAULGVWBINFP-UHFFFAOYSA-N |
M4205 (IDRX-42) is an oral, selective inhibitor of the receptor tyrosine kinase KIT with broad activity against mutations in KIT exons 11, 13, and 17. By targeting oncogenic KIT signaling, it suppresses downstream kinase cascades and tumor cell proliferation. M4205 exhibits significant and dose-dependent antitumor activity in gastrointestinal stromal tumor xenograft models driven by KIT mutations. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
6 mg/mL
(11.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.