CAS No. 2088939-99-3
Batch:
Purity:99.36
Chemical Structure
Check the
LYN-1604
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(naphthalen-2-ylmethoxy)ethyl]piperazin-1-yl]ethanone | |
|---|---|---|
| CAS Number | 2088939-99-3 | |
| Molecular Formula |
C33H45Cl4N3O2 |
|
| Molecular Weight (MW) | 657.54 | |
| SMILES | CC(C)CN(CC(C)C)CC(=O)N1CCN(CC1)CC(C2=C(C=C(C=C2)Cl)Cl)OCC3=CC4=CC=CC=C4C=C3 | |
| InChIKey | DVNVYWLKGWAELS-UHFFFAOYSA-N |
LYN-1604 is a potent ULK1 agonist that binds wild-type ULK1 with a Kd of 291.4 nM and inhibits MDA-MB-231 triple-negative breast cancer cell viability with an IC50 of 1.66 μM. Interaction with the ULK1 active site depends on specific residues, as the Y89A mutation markedly reduces binding affinity. Activation of ULK1 triggers downstream autophagic signaling, promoting autophagy-dependent cell death in breast cancer cells. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
| DMSO |
50 mg/mL
(76.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.