CAS No. 3053857-55-6
Batch:
Purity:99.28
Chemical Structure
Check the
LYG-409
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 3053857-55-6 | |
|---|---|---|
| Molecular Formula |
C25H20F3N3O6 |
|
| Molecular Weight (MW) | 515.44 |
Biological Activity
LYG-409 is a potent, selective, and orally bioavailable degrader of GSPT1 (G1 to S phase transition 1). By targeting GSPT1 for proteasomal degradation, it disrupts translation termination and suppresses cellular protein synthesis, driving robust antiproliferative activity in acute myeloid leukemia and prostate cancer cells. Selective depletion of GSPT1 impairs cellular survival pathways and demonstrates significant antitumor efficacy in vivo. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(194.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.