CAS No. 2409131-50-4
Chemical Structure
Check the
LY3499446
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2409131-50-4 | |
|---|---|---|
| Molecular Formula |
LY3499446 is a potent inhibitor of KRAS G12C that targets the mutant cysteine residue in K-Ras G12C proteins. By inhibiting KRAS G12C, it disrupts downstream RAS signaling pathways, including the MAPK/ERK pathway, leading to suppression of cellular proliferation in mutant RAS-driven cancer models. This compound is widely utilized in oncology research focusing on advanced solid tumors, particularly non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). [1]
Note: Technical data last updated: Sep 1, 2026.