CAS No. 1627696-53-0
Batch:
Purity:99.37
Chemical Structure
Check the
LY3143921 hydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3R)-3-(5-fluoropyrimidin-4-yl)-3-methyl-6-(1H-pyrazol-4-yl)-2H-isoindol-1-one;hydrate | |
|---|---|---|
| CAS Number | 1627696-53-0 | |
| Molecular Formula |
C16H14FN5O2 |
|
| Molecular Weight (MW) | 327.31 | |
| SMILES | CC1(C2=C(C=C(C=C2)C3=CNN=C3)C(=O)N1)C4=NC=NC=C4F.O | |
| InChIKey | WSICFXBHDWUFRU-PKLMIRHRSA-N |
LY3143921 hydrate is an orally bioavailable, ATP-competitive inhibitor of cell division cycle 7 (CDC7) kinase. By inhibiting the CDC7/DBF4 kinase complex, it blocks the phosphorylation of minichromosome maintenance complex component 2 (MCM2) at serine 53. This targeted inhibition disrupts the initiation of DNA replication, inducing replication stress, S-phase cell cycle arrest, and apoptosis in proliferating cancer cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(198.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 32 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.