LY294002 is a potent, reversible, ATP-competitive PI3K inhibitor. It affects PI3K/Akt/mTOR and NF-κB signaling by binding to the PI3K ATP-binding site and blocking Akt phosphorylation, effectively inhibiting cell proliferation, EMT, and angiogenesis while promoting apoptosis.
LY294002 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for LY294002 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.