CAS No. 1206799-15-6

Batch: Purity:99.78
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Merestinib (LY2801653) Chemical Structure
Chemical Structure
Check the Merestinib (LY2801653) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[3-fluoro-4-[1-methyl-6-(1H-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide
CAS Number 1206799-15-6
Molecular Formula

C30H22F2N6O3
Molecular Weight (MW) 552.53
SMILES CC1=CC=C(C(=O)N1C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C=C5C(=C4)C=NN5C)C6=CNN=C6)F
InChIKey QHADVLVFMKEIIP-UHFFFAOYSA-N

Ordering Information

Biological Activity

Merestinib (LY2801653) is a type-II ATP-competitive inhibitor targeting MET (Ki 2 nM), AXL (IC50 2 nM), FLT3, MERTK, MST1R, and DDR1. By suppressing receptor tyrosine kinase auto-phosphorylation, it impairs downstream MET and AXL signal transduction, inhibiting tumor cell proliferation, migration, and survival across multiple oncogenic models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (180.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.