CAS No. 1234703-40-2
Batch:
Purity:99.74
Chemical Structure
Check the
LY2608204
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1234703-40-2 | |
|---|---|---|
| Molecular Formula |
C28H37N3O3S3 |
|
| Molecular Weight (MW) | 559.81 | |
| SMILES | C1CCC(CC1)C2CC2(C3=CC=C(C=C3)S(=O)(=O)C4CC4)C(=O)NC5=NC=C(S5)SCCN6CCCC6 |
LY2608204 is a potent activator of glucokinase (GK). By binding to an allosteric site on glucokinase, it enhances the enzyme's affinity for glucose and increases metabolic flux through the glycolytic pathway. This activation stimulates glucose-dependent insulin secretion in pancreatic beta-cells while promoting hepatic glucose uptake and glycogen synthesis, thereby supporting systemic glucose homeostasis. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
112 mg/mL
(200.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 35 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(178.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.