CAS No. 886047-22-9
| CAS Number | 886047-22-9 | |
|---|---|---|
| Molecular Formula |
C19H24ClN5O3S |
|
| Molecular Weight (MW) | 437.94 | |
| SMILES | CC1=C2C(=C(SC2=NC(=C1Cl)OCC(=O)N3CCN(CC3)C)C(=O)NC4CC4)N |
LY2119620 is a specific allosteric agonist and positive allosteric modulator targeting human M2 and M4 muscarinic acetylcholine receptors. By binding to an extracellular allosteric site on the M2 receptor, it stabilizes the active receptor conformation and enhances orthosteric agonist signaling. This activation selectively modulates G protein-coupled signaling pathways, resulting in downstream inhibition of adenylate cyclase and altered cellular excitability. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(198.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.