CAS No. 2750830-09-0

Batch: Purity:99.43
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Luxdegalutamide (ARV-766) Chemical Structure
Chemical Structure
Check the Luxdegalutamide (ARV-766) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[4-[[1-[4-[[3-(4-cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl]carbamoyl]phenyl]piperidin-4-yl]methyl]piperazin-1-yl]-N-[(3S)-2,6-dioxopiperidin-3-yl]-2-fluorobenzamide
CAS Number 2750830-09-0
Molecular Formula

C45H54FN7O6
Molecular Weight (MW) 807.95
InChIKey RDPPBRKNBBXPNZ-PJXMSJPKSA-N

Ordering Information

Biological Activity

Luxdegalutamide (ARV-766) is an orally active proteolysis targeting chimera (PROTAC) degrader that targets the androgen receptor (AR). It effectively degrades both wild-type AR and key ligand-binding domain mutants, including LH, HY, and TA. Targeted ubiquitination and proteasomal degradation of AR suppress androgen receptor-mediated signaling pathways, leading to inhibited cellular proliferation and tumor growth in castration-resistant prostate cancer models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (123.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.