CAS No. 497871-47-3

Batch: Purity:99.81
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Lurbinectedin (PM01183) Chemical Structure
Chemical Structure
Check the Lurbinectedin (PM01183) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(1R,2R,3R,11S,12S,14R,26R)-5,12-dihydroxy-6,6'-dimethoxy-7,21,30-trimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-2,3,4,9-tetrahydropyrido[3,4-b]indole]-22-yl] acetate
CAS Number 497871-47-3
Molecular Formula

C41H44N4O10S
Molecular Weight (MW) 784.87
SMILES CC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)O)COC(=O)C8(CS5)C9=C(CCN8)C2=C(N9)C=CC(=C2)OC)OCO7)C)OC(=O)C)C(=C1OC)O
InChIKey YDDMIZRDDREKEP-HWTBNCOESA-N

Ordering Information

Biological Activity

Lurbinectedin (PM01183) is a synthetic alkaloid and DNA minor groove covalent binder with potent antitumor activity. By forming covalent adducts in the DNA minor groove, lurbinectedin inhibits active transcription through the suppression of RNA polymerase II and induces double-strand DNA breaks. These molecular disruptions alter tumor cell cycle dynamics, ultimately blocking cancer cell proliferation and triggering apoptotic cell death.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.