CAS No. 313368-91-1
Batch:
Purity:99.03
Chemical Structure
Check the
Lumateperone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 313368-91-1 | |
|---|---|---|
| Molecular Formula |
C24H28FN3O |
|
| Molecular Weight (MW) | 393.50 |
Lumateperone (ITI-007) is a potent small-molecule antagonist of the 5-HT2A receptor. By selectively blocking 5-HT2A receptor activity, it modulates serotonin and dopamine signaling pathways in the central nervous system, influencing downstream intracellular signaling cascades. This modulation regulates neuroreceptor activity, synaptic plasticity, and cellular processes associated with central nervous system function and behavioral responses in disease models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(200.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 79 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.