CAS No. 1187020-80-9

Batch: Purity:98.40
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Lumateperone Tosylate Chemical Structure
Chemical Structure
Check the Lumateperone Tosylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-(4-fluorophenyl)-4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one;4-methylbenzenesulfonic acid
CAS Number 1187020-80-9
Molecular Formula

C24H28FN3O.C7H8O3S
Molecular Weight (MW) 565.70
InChIKey LHAPOGAFBLSJJQ-GUTACTQSSA-N

Ordering Information

Biological Activity

Lumateperone tosylate (ITI-007) is a potent antagonist of 5-HT2A receptors, a presynaptic D2 receptor partial agonist, a postsynaptic D2 receptor antagonist, and a modulator of dopamine D1 receptors. Through the dual modulation of serotonergic and dopaminergic signaling pathways, lumateperone tosylate regulates downstream neuronal signaling cascades, attenuates behavioral deficits in animal models, and demonstrates anticancer activity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (176.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.