CAS No. 1058137-23-7

Batch: Purity:99.58
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Lucitanib (E3810) hydrochloride Chemical Structure
Chemical Structure
Check the Lucitanib (E3810) hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide
CAS Number 1058137-23-7
Molecular Formula

C26H26ClN3O4
Molecular Weight (MW) 479.96
SMILES [Cl-].CNC(=O)C1=CC=CC2=C1C=CC(=C2)OC3=CC=NC4=CC(=C(OC)C=C34)OCC5([NH3+])CC5
InChIKey CUDVHEFYRIWYQD-UHFFFAOYSA-N

Ordering Information

Biological Activity

Lucitanib (E3810) hydrochloride is a potent dual vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor targeting VEGFR1, VEGFR2, VEGFR3 (IC50 10 nM), FGFR1, and FGFR2. By suppressing VEGFR and FGFR signaling, it blocks endothelial cell proliferation, migration, and angiogenesis, suppressing tumor growth in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 59 mg/mL (122.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 59 mg/mL
Ethanol 30 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.