CAS No. 171714-84-4
Batch:
Purity:98.69
Chemical Structure
Check the
Lu-135252
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 171714-84-4 | |
|---|---|---|
| Molecular Formula |
C22H22N2O6 |
|
| Molecular Weight (MW) | 410.42 | |
| SMILES | COC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)OC |
Lu-135252 (Darusentan) is a selective endothelin A receptor antagonist. By binding to endothelin A receptors, Lu-135252 inhibits endothelin-1-driven intracellular calcium mobilization, phospholipase C activation, and downstream ERK/MAPK signaling pathways. This targeted receptor inhibition effectively suppresses vascular smooth muscle cell contraction, cellular proliferation, and hypertrophic responses, thereby blunting endothelin-1-mediated vasoconstriction and structural cell remodeling. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.