CAS No. 1919820-28-2

Batch: Purity:99.48
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LTI-291 Chemical Structure
Chemical Structure
Check the LTI-291 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5,7-dimethyl-N-(4-pentoxycyclohexyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS Number 1919820-28-2
Molecular Formula

C20H30N4O2

 
Molecular Weight (MW) 358.48
SMILES CCCCCOC1CCC(CC1)NC(=O)C2=C3N=C(C=C(N3N=C2)C)C
InChIKey HZILSILAELSWKN-UHFFFAOYSA-N

Biological Activity

LTI-291 is a small-molecule activator of glucocerebrosidase (GCase). By enhancing GCase catalytic activity, LTI-291 restores lysosomal lipid metabolism and reduces the accumulation of toxic glycosphingolipid substrates. Consequently, restoration of GCase function rescues the autophagy-lysosome pathway, promotes the clearance of intracellular α-synuclein aggregates, and protects against neurodegenerative phenotypes in models of Parkinson's disease. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 72 mg/mL
DMSO 36 mg/mL (100.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Sidransky E, et al. N Engl J Med. 2009;361(17):1651-61.

[2] Mazzulli JR, et al. Cell. 2011;146(1):37-52.

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Note: Technical data last updated: Sep 1, 2026.