CAS No. 1234480-84-2
Batch:
Purity:99.61
Chemical Structure
Check the
LRRK2-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one | |
|---|---|---|
| CAS Number | 1234480-84-2 | |
| Molecular Formula |
C31H38N8O3 |
|
| Molecular Weight (MW) | 570.69 | |
| SMILES | CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC | |
| InChIKey | IWMCPJZTADUIFX-UHFFFAOYSA-N |
LRRK2-IN-1 is a potent kinase inhibitor targeting LRRK2 (G2019S) and LRRK2 (WT). It acutely inhibits LRRK2 kinase activity in cellular models, leading to complete dephosphorylation of LRRK2 at Ser910 and Ser935. This compound disrupts LRRK2-mediated signaling pathways, suppressing cellular phosphorylation cascades and providing a key tool for dissecting LRRK2-dependent mechanisms in neurodegenerative disorders. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(175.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.