CAS No. 3063346-83-5
Batch:
Purity:99.13
Chemical Structure
Check the
LRK-4189
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 3063346-83-5 | |
|---|---|---|
| Molecular Formula |
C43H49F2N9O4 |
|
| Molecular Weight (MW) | 793.91 |
LRK-4189 is an orally active degrader targeting the lipid kinase PIP4K2C. Target-specific depletion of PIP4K2C activates intracellular interferon signaling pathways in microsatellite-stable colorectal cancer models. Consequently, PIP4K2C degradation by LRK-4189 promotes immunogenic tumor cell death and endogenous apoptosis, while effectively sensitizing microsatellite-stable colorectal tumors to natural killer cell killing and dendritic cell phagocytosis to stimulate anti-tumor immune responses. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(125.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.