CAS No. 195822-23-2
Batch:
Purity:99.96
Chemical Structure
Check the
LQZ-7I
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-N,3-N-bis(4-fluorophenyl)quinoxaline-2,3-diamine | |
|---|---|---|
| CAS Number | 195822-23-2 | |
| Molecular Formula |
C₂₀H₁₄F₂N₄ |
|
| Molecular Weight (MW) | 348.35 | |
| SMILES | FC1=CC=C(NC2=NC3=CC=CC=C3N=C2NC4=CC=C(F)C=C4)C=C1 | |
| InChIKey | DKPCKOKYSVPFEB-UHFFFAOYSA-N |
LQZ-7I is a selective inhibitor of survivin dimerization, displaying antiproliferative activity in PC-(ICof.8 µM) and C-2 (ICof.1 µM) prostate cancer cell lines. Disruption of survivin dimerization induces proteasome-dependent degradation of survivin, leading to apoptosis and impaired cell survival. Furthermore, oral administration of LQZ-7I effectively suppresses xenograft tumor growth and induces survivin loss in tumors in vivo. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(200.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 70 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.