CAS No. 80382-23-6
Batch:
Purity:99.98
Chemical Structure
Check the
Loxoprofen Sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | sodium 2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoate | |
|---|---|---|
| CAS Number | 80382-23-6 | |
| Molecular Formula |
C15H17O3.Na |
|
| Molecular Weight (MW) | 268.28 | |
| SMILES | CC(C1=CC=C(C=C1)CC2CCCC2=O)C(=O)[O-].[Na+] | |
| InChIKey | WORCCYVLMMTGFR-UHFFFAOYSA-M |
Loxoprofen sodium is a non-steroidal anti-inflammatory prodrug that targets cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) following conversion to its active trans-alcohol metabolite. By inhibiting COX-mediated arachidonic acid metabolism, it reduces the biosynthesis of pro-inflammatory prostaglandins such as prostaglandin E2 (PGE2). This blockade of COX pathways effectively attenuates downstream inflammatory signaling and pain responses in preclinical models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 53 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.