CAS No. 2833703-74-3
Chemical Structure
Check the
LOXO-435
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[4-[3-chloro-4-[(1S)-1-(5-fluoro-2-pyridinyl)-2-hydroxyethoxy]pyrazolo[1,5-a]pyridin-6-yl]-5-methyltriazol-1-yl]piperidine-1-carbonitrile | |
|---|---|---|
| CAS Number | 2833703-74-3 | |
| Molecular Formula |
C23H22ClFN8O2 |
|
| Molecular Weight (MW) | 496.93 | |
| InChIKey | OYUCEQFRNJABJW-OAQYLSRUSA-N |
Vepugratinib (LOXO-435) is a potent and isoform-selective small-molecule inhibitor targeting fibroblast growth factor receptor 3 (FGFR3), engineered to retain activity against FGFR3 gatekeeper mutations. By suppressing FGFR3 kinase activity, it blocks downstream FGFR signaling pathways to inhibit cell proliferation and induce apoptosis in FGFR3-altered cancer cells. The compound exhibits potential antitumor activity in models of FGFR3-driven solid tumors, particularly metastatic urothelial carcinoma. [1][2]
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Note: Technical data last updated: Sep 1, 2026.