CAS No. 1223405-08-0
Batch:
Purity:99.76
Chemical Structure
Check the
Larotrectinib sulfate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide;sulfuric acid | |
|---|---|---|
| CAS Number | 1223405-08-0 | |
| Molecular Formula |
C21H22F2N6O2.H2SO4 |
|
| Molecular Weight (MW) | 526.51 | |
| SMILES | C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F.OS(=O)(=O)O | |
| InChIKey | PXHANKVTFWSDSG-QLOBERJESA-N |
Larotrectinib sulfate is a potent, selective, ATP-competitive inhibitor of tropomyosin receptor kinases, including TRKA, TRKB, and TRKC. Inhibition of TRK kinase activity suppresses downstream signaling pathways such as MAPK/ERK and PI3K/AKT. This targeted pathway blockade impairs oncogenic signal transduction, leading to cell proliferation inhibition, G1 cell-cycle arrest, and the induction of cellular apoptosis in TRK-dependent tumor cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(189.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(189.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(189.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(189.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Larotrectinib sulfate Clinical Trials
- Larotrectinib sulfate Solubility in DMSO
- Larotrectinib sulfate Stock Solution
- Larotrectinib sulfate Storage
- Larotrectinib sulfate Stability
- Larotrectinib sulfate Molecular Weight
- Larotrectinib sulfate SMILES
- Larotrectinib sulfate Chemical Structure (2D and 3D)
- Larotrectinib sulfate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.