CAS No. 2409964-23-2

Batch: Purity:99.99
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LOX-IN-3 Dihydrochloride Chemical Structure
Chemical Structure
Check the LOX-IN-3 Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (Z)-3-fluoro-4-quinolin-8-ylsulfonylbut-2-en-1-amine;dihydrochloride
CAS Number 2409964-23-2
Molecular Formula

C13H13FN2O2S.2ClH
Molecular Weight (MW) 353.24
SMILES Cl.Cl.NC\C=C(/F)C[S](=O)(=O)C1=CC=CC2=C1N=CC=C2
InChIKey YYYHSAUHJBNINZ-LEOXJOGCSA-N

Ordering Information

Biological Activity

LOX-IN-Dihydrochloride is an orally active, selective lysyl oxidase (LOX) inhibitor targeting LOX family enzymes. By inhibiting enzyme-mediated collagen and elastin cross-linking within the extracellular matrix, it prevents fibrotic tissue remodeling and extracellular matrix accumulation. In preclinical rodent models, LOX-IN-attenuates multi-organ fibrosis, suppresses alpha-smooth muscle actin expression, reduces dermal thickness, and normalizes collagen crosslink formation in skin and lung tissues. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 71 mg/mL (200.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 71 mg/mL
Ethanol 5 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.