CAS No. 2401892-75-7
Batch:
Purity:99.01
Chemical Structure
Check the
Lotiglipron
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]piperidin-1-yl]methyl]-3-[[(2S)-oxetan-2-yl]methyl]benzimidazole-5-carboxylic acid | |
|---|---|---|
| CAS Number | 2401892-75-7 | |
| Molecular Formula |
C31H31ClN4O5 |
|
| Molecular Weight (MW) | 575.06 | |
| InChIKey | SVPYZAJTWFQTSM-UGDMGKLASA-N |
Lotiglipron (PF- is an orally active agonist of the glucagon-like peptide-1 receptor (GLP-1R). Selective activation of GLP-1R stimulates intracellular cAMP signaling, leading to enhanced glucose-dependent insulin secretion and inhibition of glucagon release. Through these metabolic signaling cascades, lotiglipron improves glycemic control, lowers blood glucose levels, and reduces body weight in experimental models of type 2 diabetes mellitus and obesity. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(173.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.