CAS No. 114798-26-4

Batch: Purity:99.99
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Losartan Chemical Structure
Chemical Structure
Check the Losartan product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 114798-26-4
Molecular Formula

C22H23ClN6O
Molecular Weight (MW) 422.91
SMILES CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl

Biological Activity

Losartan (DuP-753) is a selective, nonpeptide angiotensin II type 1 (AT1) receptor antagonist. By blocking the binding of angiotensin II to the AT1 receptor, it inhibits angiotensin II-mediated vasoconstriction and aldosterone release. Blockade of this signaling pathway attenuates vascular smooth muscle contraction, reduces cell proliferation, and modulates renal vascular resistance in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (198.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Chiu AT, et al. J Pharmacol Exp Ther. 1990;252(2):711-8.

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Note: Technical data last updated: Sep 1, 2026.