CAS No. 1820940-17-7
Batch:
Purity:99.72
Chemical Structure
Check the
Lorundrostat
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-(4-acetamidocyclohexyl)-2-[4-[5-(4-methylphenyl)-1,2,4-triazin-3-yl]piperazin-1-yl]acetamide | |
|---|---|---|
| CAS Number | 1820940-17-7 | |
| Molecular Formula |
C24H33N7O2 |
|
| Molecular Weight (MW) | 451.57 | |
| InChIKey | YHGVDZULVMINCJ-UHFFFAOYSA-N |
Biological Activity
Lorundrostat (MT- is a selective aldosterone synthase inhibitor targeting hCYP11B2 and hCYP11B1. By selectively suppressing CYP11B2-mediated aldosterone biosynthesis, it attenuates mineralocorticoid receptor pathway activation and downstream renal tubular signaling without impairing cortisol production. This target inhibition downregulates dysregulated mineralocorticoid pathways involved in fluid-electrolyte homeostasis and arterial pressure regulation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
4 mg/mL
(8.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.