CAS No. 1454846-35-5

Batch: Purity:99.95
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Lorlatinib (PF-6463922) Chemical Structure
Chemical Structure
Check the Lorlatinib (PF-6463922) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile
CAS Number 1454846-35-5
Molecular Formula

C21H19FN6O2
Molecular Weight (MW) 406.41
SMILES CC1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
InChIKey IIXWYSCJSQVBQM-LLVKDONJSA-N

Ordering Information

Biological Activity

Lorlatinib (PF-06463922) is a potent macrocyclic dual ALK and ROS1 inhibitor that targets ALK (WT) (Ki <, ALK (L1196M) (Ki, and ROS1 (Ki <. Inhibition of ALK and ROS1 kinase activity blocks downstream STAT3, AKT/mTOR, and ERK signaling pathways, suppressing cell proliferation and inducing apoptosis in ALK- or ROS1-driven cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 81 mg/mL (199.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 40.5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.