CAS No. 1353867-91-0
Batch:
Purity:99.87
Chemical Structure
Check the
Longdaysin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 9-propan-2-yl-N-[[3-(trifluoromethyl)phenyl]methyl]purin-6-amine | |
|---|---|---|
| CAS Number | 1353867-91-0 | |
| Molecular Formula |
C16H16F3N5 |
|
| Molecular Weight (MW) | 335.33 | |
| SMILES | CC(C)N1C=NC2=C(N=CN=C21)NCC3=CC(=CC=C3)C(F)(F)F | |
| InChIKey | REKSFCCYDQMSIN-UHFFFAOYSA-N |
Biological Activity
Longdaysin is a casein kinase inhibitor that targets CKIα (IC50 =, CKIδ (IC50 =, CDK7 (IC50 =, and ERK2 (IC50 =. By inhibiting casein kinase 1 isoforms and downstream regulatory kinases, Longdaysin suppresses phosphorylation of clock proteins and alters circadian feedback loops, leading to marked period lengthening in mammalian circadian clock systems. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 67 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.