CAS No. 202914-84-9

Batch: Purity:99.75
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Lomitapide Mesylate Chemical Structure
Chemical Structure
Check the Lomitapide Mesylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methanesulfonic acid;N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
CAS Number 202914-84-9
Molecular Formula

C40H41F6N3O5S 
Molecular Weight (MW) 789.83
SMILES CS(=O)(=O)O.C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F
InChIKey QKVKOFVWUHNEBX-UHFFFAOYSA-N

Ordering Information

Biological Activity

Lomitapide Mesylate is a potent inhibitor of microsomal triglyceride transfer protein (MTP). By inhibiting MTP activity within the lumen of the endoplasmic reticulum, it prevents the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins, including very low-density lipoproteins and chylomicrons. This targeted blockade disrupts hepatic and intestinal lipid transport pathways, thereby suppressing lipid secretion and reducing circulating triglyceride and cholesterol accumulation.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (126.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.