CAS No. 139755-85-4
Batch:
Purity:99.93
Chemical Structure
Check the
Lodenafil
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-[2-ethoxy-5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,5-d]pyrimidin-7-one | |
|---|---|---|
| CAS Number | 139755-85-4 | |
| Molecular Formula |
C23H32N6O5S |
|
| Molecular Weight (MW) | 504.6 | |
| SMILES | CCCC1=N[N](C)C2=C1NC(=NC2=O)C3=C(OCC)C=CC(=C3)[S;v6](=O)(=O)N4CCN(CCO)CC4 | |
| InChIKey | NEYKRKVLEWKOBI-UHFFFAOYSA-N |
Biological Activity
Lodenafil is a potent inhibitor of phosphodiesterase type 5 (PDE5). Targeted inhibition of PDE5 prevents the enzymatic breakdown of cyclic guanosine monophosphate (cGMP), thereby strengthening nitric oxide (NO)/cGMP signaling pathways in vascular tissue. This accumulation of intracellular cGMP promotes cavernous smooth muscle relaxation and tissue vasodilation, ultimately enhancing vascular responsiveness and erectile tissue relaxation.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(198.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 13 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.