CAS No. 129277-38-9
Batch:
Purity:99
Chemical Structure
Check the
Lobetyolin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,3R,4S,5S,6R)-2-[(4E,6R,7R,12E)-1,7-dihydroxytetradeca-4,12-dien-8,10-diyn-6-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol | |
|---|---|---|
| CAS Number | 129277-38-9 | |
| Molecular Formula |
C20H28O8 |
|
| Molecular Weight (MW) | 396.43 | |
| InChIKey | MMMUDYVKKPDZHS-MXFZCOKBSA-N |
Lobetyolin is a natural polyacetylene glycoside bioactive compound derived from Codonopsis pilosula that targets alanine-serine-cysteine transporter 2 (ASCT2). It significantly downregulates ASCT2 mRNA and protein expression, thereby suppressing cellular glutamine metabolism pathways. Consequently, this downregulation contributes to drug-induced apoptosis, inhibits tumor cell proliferation, and provides a protective effect against gastric mucosal damage in epithelial tissues. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 79 mg/mL |
| Ethanol | 79 mg/mL |
| DMSO |
20 mg/mL
(50.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.