CAS No. 1793053-37-8

Batch: Purity:99.78
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LLY-507 Chemical Structure
Chemical Structure
Check the LLY-507 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-cyano-5-[2-[4-[2-(3-methylindol-1-yl)ethyl]piperazin-1-yl]phenyl]-N-(3-pyrrolidin-1-ylpropyl)benzamide
CAS Number 1793053-37-8
Molecular Formula

C36H42N6O
Molecular Weight (MW) 574.76
SMILES CC1=CN(C2=CC=CC=C12)CCN3CCN(CC3)C4=CC=CC=C4C5=CC(=CC(=C5)C#N)C(=O)NCCCN6CCCC6
InChIKey PNYRDVBFYVDJJI-UHFFFAOYSA-N

Ordering Information

Biological Activity

LLY-507 is a potent, cell-active, and selective inhibitor of protein-lysine methyltransferase SMYD2. By suppressing SMYD2-mediated methylation of key protein substrates such as p53 and RB, it disrupts SMYD2 signaling pathways in cancer cells. Consequently, LLY-507 inhibits cell proliferation and promotes apoptotic responses in multiple cancer cell lines dependent on SMYD2 activity.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 30 mg/mL (52.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 22 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.