CAS No. 2172879-52-4

Batch: Purity:99.57
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LIT-927 Chemical Structure
Chemical Structure
Check the LIT-927 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-(4-chlorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-1H-pyrimidin-2-one
CAS Number 2172879-52-4
Molecular Formula

C17H13ClN2O3
Molecular Weight (MW) 328.75
SMILES COC1=C(C=CC(=C1)C2=NC(=O)NC(=C2)C3=CC=C(C=C3)Cl)O
InChIKey BYYRNPIGDRRGLJ-UHFFFAOYSA-N

Ordering Information

Biological Activity

LIT-927 is a novel small-molecule neutraligand targeting CXCL12, a key chemokine involved in leukocyte recruitment and inflammatory pathways. By binding directly to CXCL12, neutraligands inhibit its interaction with CXCR4 and CXCR7 receptors, thereby blocking CXCL12-induced calcium mobilization, ERK phosphorylation, and cell migration. This targeted neutralization disrupts CXCL12-mediated signaling cascades, ultimately suppressing downstream inflammatory phenotypes and cellular recruitment responses in affected tissues. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (200.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.