CAS No. 76547-98-3
Batch:
Purity:98.61
Chemical Structure
Check the
Lisinopril
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid | |
|---|---|---|
| CAS Number | 76547-98-3 | |
| Molecular Formula |
C21H31N3O5 |
|
| Molecular Weight (MW) | 405.49 | |
| InChIKey | RLAWWYSOJDYHDC-BZSNNMDCSA-N |
Lisinopril is a synthetic peptide derivative that functions as a potent inhibitor of angiotensin-converting enzyme (ACE). By selectively inhibiting ACE, it blocks the conversion of angiotensin I to the potent vasoconstrictor angiotensin II, leading to reduced systemic vascular resistance and decreased aldosterone secretion. This suppression of the renin-angiotensin-aldosterone system attenuates vascular smooth muscle contraction, lowers blood pressure, and reduces cardiac workload. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 20 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.