CAS No. 1345982-69-5
Batch:
Purity:99.99
Chemical Structure
Check the
Linerixibat
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1345982-69-5 | |
|---|---|---|
| Molecular Formula |
C28H38N2O7S |
|
| Molecular Weight (MW) | 546.68 |
Linerixibat is a nonabsorbable inhibitor of the apical sodium-dependent bile acid transporter (ASBT, IC50 42 nM), also known as ileal bile acid transporter (IBAT). By selectively blocking ASBT-mediated bile acid reabsorption in the terminal ileum, it interrupts enterohepatic bile acid circulation. This targeted inhibition reduces systemic bile acid accumulation and mitigates downstream signaling pathways responsible for cholestatic pruritus. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(91.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.